S-Adenosyl Methionine (SAMe) is a sulfur-containing amino acid produced primarily in the liver and not found in food. It can be formed in the body from a combination of adenosine triphosphate (ATP) and the amino acid L-methionine. SAMe plays a role in sulfur transfer in the body and is converted, through the methionine cycle, into cysteine, which can be converted back into glutathione or taurine. SAMe also plays a role in the formation of creatine, which is important for athletes. Melatonin requires SAMe as a methyl donor. As we age, our body's ability to produce SAMe declines.
We cannot obtain SAMe from our diet. The amino acid methionine can be found in the diet, but it is a less efficient way to supplement SAMe. Sometimes SAMe production is deficient and decreases with age. In these cases, supplementing this essential amino acid with a dietary supplement can provide a solution.

The benefits of the SAMe-400 complex from Bonusan

Bonusan SAMe-400 capsules are easy to dose. One capsule contains 400 mg of SAMe-disulfate tosylate, providing 200 mg of SAMe, naturally occurring S-adenosylmethionine. In scientific studies, a multiple of 200 mg of SAMe is always used. We recommend starting with a dose of one to three capsules per day (200 to 600 mg of active SAMe). It is best to increase the daily dose of SAMe slowly. In some cases, taking a higher dose (800 to 1200 mg per day) for several weeks can be helpful. In therapeutic treatments, a dose of 800-1600 mg per day is effective. When taking SAMe orally, it is best taken on an empty stomach or half an hour before meals.
Because SAMe is a naturally occurring substance in the body, it is readily absorbed. Benefits are quickly experienced after starting SAMe supplementation. Bonusan's SAMe-400 complex is often popular and well-tolerated because the natural raw material has few, if any, side effects.

High quality thanks to stabilized SAMe

The SAMe contained in Bonusan's SAMe-400 is produced through fermentation. Fermentation produces only the S,S SAMe (spatial form). We use this spatial form in our products because it's the form naturally produced in the body, allowing us to closely replicate the natural form. The synthetic R,S form has a different spatial configuration, meaning it cannot be utilized by the body. Therefore, we do not include this synthetic form in our supplement.
The SAMe used in Bonusan SAMe-400 is stabilized. The bond with tosylate disulfate makes our raw material the most stable form of SAMe. Unstabilized and unprotected SAMe is very sensitive to heat and humidity and will quickly lose its effectiveness. Due to this high sensitivity to humidity, manufacturing high-quality SAMe requires a meticulous production process. The entire process in our factory is designed accordingly, from raw materials to the finished product. To ensure the high quality of Bonusan SAMe-400 even outside our factory, we package the capsules hermetically in blister packs. We also recommend that the product not be stored in humid areas, such as the kitchen or bathroom. This way, you maintain the best possible quality until the product's expiration date.

Suitable for complementing the body's own SAMe

One Bonusan SAMe-400 capsule contains 400 mg of SAMe-disulfate tosylate, providing 200 mg of naturally occurring SAMe, S-adenosylmethionine. When the body's own production is insufficient or declines with age, this carefully produced SAMe-400 complex offers a solution. SAMe can be beneficial at a variety of dosages. Determining the correct dosage is often part of a therapeutic approach. In cases where a high dose is required, gradually increasing the daily dose can help prevent nausea and gastrointestinal discomfort. We recommend consulting a healthcare professional when using SAMe. Bonusan's SAMe-400 complex contains no animal-derived ingredients and is therefore suitable for vegetarians and vegans.