FOLAMET

Description
This food for special medical purposes (FSMP) is indicated for the dietary management of hyperhomocysteinemia resulting from a genetic deficiency of the enzyme methylenetetrahydrofolate reductase (MTHFR), also known as folic acid genetic polymorphism. L-5-methylfolate is the metabolically active form of folic acid and, through the transfer of a methyl group, can convert homocysteine ​​back to methionine even in the presence of a genetic deficiency. Vitamins B2, B6, B12, and zinc are enzymatic cofactors that enhance the activity of L-5-methylfolate in controlling hyperhomocysteinemia.
Levo-5-methylfolate or methylfolate (6S-5-Methyl-THF or MTHF) is the biologically active form of folate, is naturally present in our body and represents 98% of plasma folate. Bioavailability studies have shown that methylfolate supplementation is effective in improving both plasma and erythrocyte folate levels. Methylfolate does not require biotransformation by either the dihydrofolate reductase (DHFR) or the methylenetetrahydrofolate reductase (MTHFR) enzymes. Therefore, the bioavailability of methylfolate is not limited by the saturation of these enzymes, and its intake does not result in the presence of unmetabolized forms of folate in the blood. Methylfolate is therefore not affected by functional polymorphisms of the MTHFR and DHFT genes. Methylfolate has a lower risk of interaction with DHFR-inhibiting drugs (e.g., methotrexate) and is less likely to mask hematological symptoms resulting from vitamin B12 deficiency in patients with pernicious anemia. Furthermore, methylfolate is stable when exposed to visible light and UV radiation. Therefore, under conditions of sunlight exposure, methylfolate supplementation ensures stable blood folate levels that cannot be guaranteed by other folates. In conclusion, methylfolate is able to correct hyperhomocysteinemia even in the presence of genetic mutations and enzyme polymorphisms related to folate metabolism.

Ingredients
Calcium L-5-methylfolate (vitamin B9), vitamin B2, vitamin B6, vitamin B12, zinc oxide.

How to use
It is recommended to take 1 tablet per day, unless otherwise prescribed by your doctor.

Warnings
The product must be used under medical supervision.

Conservation
Store in a cool, dry place.
Shelf life in intact packaging: 36 months.

Format
Pack of 30 tablets.
Net weight: 15 g.