MAQUI 500

Description
A maqui-based dietary supplement for activating energy processes, regulating cellular metabolism, and combating free radicals, thus providing anti-aging benefits. Maqui 500 is a unique supplement in terms of dose and quality: each tablet contains 500 mg of freeze-dried maqui fruit with an antioxidant power of 70,000 mcmol TE/100 g on the ORAC scale (see certificate available at www.proeon.it), a value more than double that of the maqui berry. It is chewable and can also be taken sublingually. The demonstrated effects of Maqui, in accordance with international literature, are:
-antioxidant, anti-free radicals, therefore against inflammation and cellular aging ("inflammaging") (1- 7);
-activity on the cardiovascular system, reducing the level of some lipids in the blood, controlling blood sugar and improving blood flow (3-5, 7-9);
-indirect contribution to body weight reduction (2, 3, 7);
-positive interaction in degenerative brain and eye diseases (3, 10);
-antidiarrheal and intestinal flora regulating activity (11);
-protection of the skin from photoaging and strengthening action on the hair (3);
-improvement of bronchopulmonary conditions in smokers (12);
-stimulation of the immune system (1, 12).
Maqui 500 contains no gluten or sweeteners, is GMO free and Vegan OK.

Ingredients
Maqui [Aristotelia chilensis (Mol.) Stuntz.] freeze-dried fruit on corn maltodextrin; bulking agent: microcrystalline cellulose; anti-caking agents: vegetable magnesium stearate, colloidal silica.

Gluten free.

Nutritional characteristics

Average values	For 1 tablet	For 2 tablets
Freeze-dried maqui fruit	500 mg	1,000 mg

How to use
1-2 tablets per day away from meals, with a glass of water.

Warnings
This product should be used as part of a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age.

Conservation
Store the product at room temperature.
Shelf life in intact packaging: 36 months.

Format
Pack of 30 800 mg tablets in blister pack.
Net weight: 24 g.

Bibliography
1) Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz). Escribano-Bailon MT, Alcalde-Eon C, Munoz O, Rivas-Gonzalo JC, Santos-Buelga C. Phytochem Anal 2006;17:8-14.
2) Maqui Polyphenols - The true treasure of Robinson Crusoe Island A. Zampetti 2013, sanihelp.it.
3)Nutraceutical and antioxidant effects of a delphinidin-rich maqui berry extract Delphinol: a review. Watson RR, Schönlau F Minerva Cardioangiologica 2015, 63(2 Suppl 1):1-12.
4) In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Rojo L, Ribnicky D, Logendra S, Poulev A, Rojas-Silva P, et al. Food Chemistry 2012, 13: 387-396.
5) Healthy properties of maqui berry extract. Scapagnini G, Davinelli S, Armando Z. , App Aging Control 2014;18:44-9.
6) A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol) on Oxidative Stress Biomarkers Davinelli S, Beoglio JC, Zarrelli A, Pina R, Scapagnini G, Journal of the American College of Nutrition, 2015;34, No. S1, 28-33.
7) Maqui and Omega 3: effects on lipid profile, oxidative stress levels, and psychophysical items in human subjects Cavezzi A, Corsi R, Dimitrova G, Colucci R, Paccasassi S, Quinzi V, Fioroni E, Campana F, Urso S, Mosti G. Discovery Phytomedicine 2017, Volume 4, Number 2: 26-30, in publication.
8) Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae). Cespedes C, El-Hafidi M, Pavon N, Alarcon J, Food Chemistry 2008, 107: 820-829.
9) Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress. Miranda Rottmann S, Aspillaga A, Pérez D, Vásquez L, Martínez A, Leighton FJ Agric Food Chem 2002, 50(26): 7542-7.
10) Maqui Berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Tanaka J, Kadekaru T, Ogawa K, Hitoe S, Shimoda H, et al. , Food Chemistry 2013, 139: 129-137.
11) Maqui [Aristotelia chilensis (Mol.) Stuntz]-the Amazing Chilean Tree: A Review E. Misle, E. Garrido, H. Contardo and W. González Journal of Agricultural Science and Technology B 1 2011: 473-482.
12) The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers - an explorative study Vergara D, Ávila D, EscobarE, Carrasco-Pozo C, Sánchez A, Gotteland M, Nutrition Journal, 2015 14:27.